Structure and Total Synthesis of Lysobactin (Katanosin B)

Abstract

Tackle-resistant bacteria: Determination of the 3D structure of the antibiotic lysobactin has led to its total synthesis and resulted in a high-yielding macrolactamization step. The minimal use of protecting groups allowed preorganization of the side chains to steer the cyclization. Thus, a new chemical route has been developed in the search for innovative antibiotic lead structures. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z604232_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.