Total Synthesis of Platensimycin

Abstract

Beat the superbugs: The newly discovered antibiotic platensimycin (1) promises to combat current drug-resistant infections. The natural product shows potent activity against Gram-positive bacteria and contains a novel molecular architecture. The total synthesis of this intriguing natural product that opens the way to a variety of otherwise inaccessible analogues has now been achieved (calculated structure shown on the right).