Angewandte Chemie International Edition · 2006 · 189 citations · 19 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoverySynthetic Medicinal ChemistryAntibacterial PharmacologyAntibiotic ResistanceMacrocycle SynthesisMacrocyclic Drug DesignNatural Product Drug DiscoveryNatural Product-based Drug DesignAntibacterial Drug DevelopmentAntibiotic DiscoveryDrug-resistant PathogensNatural Product SynthesisNatural Product Total SynthesisNovel Antibacterial AgentsNovel Antibacterial Drug DiscoveryTotal Synthesis-derived Analogues
Beat the superbugs: The newly discovered antibiotic platensimycin (1) promises to combat current drug-resistant infections. The natural product shows potent activity against Gram-positive bacteria and contains a novel molecular architecture. The total synthesis of this intriguing natural product that opens the way to a variety of otherwise inaccessible analogues has now been achieved (calculated structure shown on the right).
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Oxidation of α,β-un saturated aldehydes
Balkrishna S. Bal, Wayne E. Childers, Harold W. Pinnick · Tetrahedron · 1981 · 1.1K citations
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang, S.M. Soisson, Katherine Young et al. · Nature · 2006 · 815 citations