Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Philippe Bouillet, Donald Metcalf, David C.S. Huang et al. · Science · 1999 · 1.5K citations

Clinical Immunology, Certain Apoptotic Responses, Preclude Autoimmunity +18

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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Tumor Biology, Medicine, Molecular Biology +8

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Andreas Villunger, Ewa M. Michalak, Leigh Coultas et al. · Science · 2003 · 1.3K citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Jian Yu, Lin Zhang, Paul M. Hwang et al. · Molecular Cell · 2001 · 1.3K citations · Full text

Apoptosis, Colorectal Cancer, Cell Death +5

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Michael Certo, Victoria Del Gaizo Moore, Mari Nishino et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Death Signals, Mitophagy, Cellular Addiction +10