Concepedia

Bh3-only Protein Function

BH3-Only Protein Function is a molecular regulatory mechanism within the intrinsic apoptotic pathway that specifically initiates cytochrome c release by selectively activating pro-apoptotic Bcl-2 family proteins through targeted protein–protein interactions.

548

Publications

58.6K

Citations

2.9K

Authors

794

Institutions

Publications per year

2017–2026

69

Parents

Publications

548

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

Lin Chen, Simon N. Willis, Andrew H. Wei et al. · Molecular Cell · 2005 · 1.8K citations · Full text

, , +13

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

Philippe Bouillet, Donald Metcalf, David C.S. Huang et al. · Science · 1999 · 1.5K citations

, , +17

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Hamsa Puthalakath, Lorraine A. O’Reilly, Priscilla Gunn et al. · Cell · 2007 · 1.4K citations · Full text

, , +14

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Andreas Villunger, Ewa M. Michalak, Leigh Coultas et al. · Science · 2003 · 1.3K citations

, , +17

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x <sub>L</sub> , but not Bcl-2, until displaced by BH3-only proteins

Simon N. Willis, Grant Dewson, Andrew H. Wei et al. · Genes & Development · 2005 · 1.2K citations · Full text

, , +17

1–5 of 548

Authors

2.9K

  1. AS
    Andreas Strasser

    Walter and Eliza Hall Institute of Medical Research, Australia

    56 publications · 12K citations

    41

    h-index

  2. DC
    David C.S. Huang

    Walter and Eliza Hall Institute of Medical Research, Australia

    29 publications · 9.9K citations

    27

    h-index

  3. PB
    Philippe Bouillet

    Walter and Eliza Hall Institute of Medical Research, Australia

    28 publications · 7.7K citations

    26

    h-index

  4. JM
    Jerry M. Adams

    Walter and Eliza Hall Institute of Medical Research, Australia

    24 publications · 10.4K citations

    24

    h-index

  5. AV
    Andreas Villunger

    Innsbruck Medical University, Austria

    28 publications · 4.1K citations

    21

    h-index

1–5 of 2.9K

Institutions

794

  1. Walter and Eliza Hall Institute of Medical Research

    Melbourne, Australia

    57 h-index

    554 publications

    147.3K citations

  2. The University of Melbourne

    Melbourne, Australia

    39 h-index

    217 publications

    39.3K citations

  3. Innsbruck Medical University

    Innsbruck, Austria

    21 h-index

    110 publications

    7.1K citations

  4. Inserm

    Paris, France

    20 h-index

    123 publications

    14.1K citations

  5. Harvard University

    Cambridge, United States

    17 h-index

    48 publications

    7.6K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    67 publications

    4.8K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    16 h-index

    51 publications

    5.8K citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    43 publications

    14K citations

1–8 of 794

Venues

  1. Journal of Biological Chemistry

    JBC · 58 publications · 8.6K citations

    44

    h-index

  2. Cell Death and Differentiation

    CDD · 34 publications · 2K citations

    25

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 24 publications · 3.2K citations

    24

    h-index

  4. Cell Death and Disease

    28 publications · 1.3K citations

    22

    h-index

  5. Cancer Research

    16 publications · 1.6K citations

    16

    h-index

1–5