Akt or phosphoinositide-3-kinase inhibition reverses cardio-protection in Toll-like receptor 2 deficient mice

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

Sandeep Robert Datta, Henryk Dudek, Xu Tao et al. · Cell · 1997 · 5.7K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Darren A.E. Cross, Dario R. Alessi, Philip Cohen et al. · Nature · 1995 · 5.2K citations

Life Sciences, Biochemistry, Molecular Biology +12

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

Yasushi Fujio, Thao Nguyen, Detlef Wencker et al. · Circulation · 2000 · 843 citations · Full text

Medicine, Cardiology, Molecular Medicine +13

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

Laurence Arbibe, Jean‐Paul Mira, Nicole Teusch et al. · Nature Immunology · 2000 · 664 citations

Life Sciences, Immunology, Molecular Biology +14