Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Host Response, Toll-like Receptors, Signal Transduction +10

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.3K citations · Full text

Toll-like Receptors, Gram-negative Bacteriology, Virulence Factor +7

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Osman Nidai Özeş, Lindsey D. Mayo, Jason A. Gustin et al. · Nature · 1999 · 2.2K citations

Inflammation, Cytokine, Tumour Necrosis Factor +15

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

Immunology, Molecular Biology, Inflammation +20

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

Julia A. Romashkova, Sergei S. Makarov · Nature · 1999 · 1.8K citations

Signaling Pathway, Receptor Tyrosine Kinase, Immunology +7