Concepedia

Assessment of Intestinal Availability of Various Drugs in the Oral Absorption Process Using Portal Vein-Cannulated Rats

Yoshiki Matsuda, Yoshihiro Konno, Masahiro Satsukawa, Taro Kobayashi, Yu Takimoto, Kunihiko Morisaki, Shinji Yamashita

Drug Metabolism and Disposition · 2012 · 46 citations · 27 references

DOI

Concepts

References

27

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

F Thiébaut, T Tsuruo, Hironobu Hamada et al. · Proceedings of the National Academy of Sciences · 1987 · 2.8K citations · Full text

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A physiological approach to hepatic drug clearance

G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations

, , +17

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance.

A Rane, G. Wilkinson, David G. Shand · Journal of Pharmacology and Experimental Therapeutics · 1977 · 328 citations

, , +17

STUDIES ON THE ABSORPTION, DISTRIBUTION AND EXCRETION OF INDOMETHACIN IN VARIOUS SPECIES

H. Hücker, Anthony G. Zacchei, S. Cox et al. · Journal of Pharmacology and Experimental Therapeutics · 1966 · 323 citations

, , +14

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

Michael Gertz, Anthony Harrison, J. Brian Houston et al. · Drug Metabolism and Disposition · 2010 · 299 citations

, , +17