Concepedia

Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014

Thomas A. Lanz, Kathleen M. Wood, K. Richter, Charles E. Nolan, Stacey L. Becker, Nikolay Pozdnyakov, Barbara‐Anne Martin, Ping Du, Christine Oborski, Douglas E. Wood,

Journal of Pharmacology and Experimental Therapeutics · 2010 · 50 citations · 36 references

DOI

Concepts

References

36

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

George G. Glenner, Caine W. Wong · Biochemical and Biophysical Research Communications · 1984 · 5.4K citations

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Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

, , +17

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Huaibin Cai, Yanshu Wang, Diane B. McCarthy et al. · Nature Neuroscience · 2001 · 1.1K citations

, , +14

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 716 citations · Full text

, , +17

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

Yue‐Ming Li, Ming‐Tain Lai, Min Xu et al. · Proceedings of the National Academy of Sciences · 2000 · 535 citations · Full text

, , +17