Christine Oborski

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 412 citations · Full text

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Ivan Efremov, F.F. Vajdos, Kris A. Borzilleri et al. · Journal of Medicinal Chemistry · 2012 · 63 citations · Full text

Pharmaceutical Science, Drug Target, Novel Spiropyrrolidine Inhibitor +21

Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors

Michael A. Brodney, Gabriela Barreiro, Kevin Ogilvie et al. · Journal of Medicinal Chemistry · 2012 · 60 citations · Full text

Drug Target, Peptide Science, Pharmacotherapy +20

Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014

Thomas A. Lanz, Kathleen M. Wood, K. Richter et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 50 citations

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

Michael A. Brodney, David D. Auperin, Stacey L. Becker et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 31 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +10