Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High‐Affinity Binding Sites in both Cross‐ and Self‐Association

Abstract

Short peptide sequences are identified as hot regions of the cross-interaction interface of the Alzheimer's disease β-amyloid peptide (Aβ) with the type 2 diabetes islet amyloid polypeptide (IAPP). They are shown to be high-affinity ligands of both Aβ and IAPP, thus suggesting common molecular recognition features in amyloid self- and cross-amyloid hetero-assembly.