Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

Limei Yan, Marianna Tatarek‐Nossol, Aleksandra Velkova, +2

Proceedings of the National Academy of Sciences

Identification of Hot Regions of the Aβ–IAPP Interaction Interface as High‐Affinity Binding Sites in both Cross‐ and Self‐Association

Erika Andreetto, Limei Yan, Marianna Tatarek‐Nossol, +3

Angewandte Chemie International Edition

Molecular BiologyPeptide SciencePeptide TherapeuticsAnalytical UltracentrifugationAlzheimer's Disease +18

IAPP Mimic Blocks Aβ Cytotoxic Self‐Assembly: Cross‐Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes

Limei Yan, Aleksandra Velkova, Marianna Tatarek‐Nossol, +2

Angewandte Chemie International Edition

Peptide SciencePeptide TherapeuticsType IiType Ii DiabetesMolecular Pharmacology +15

AtEXP2 Is Involved in Seed Germination and Abiotic Stress Response in Arabidopsis

An Yan, Minjie Wu, Limei Yan, +3

PLoS ONE

BotanyAbiotic Stress ResponseGeneticsAbiotic DamagePlant Molecular Biology +14

Inhibition of hIAPP Amyloid-Fibril Formation and Apoptotic Cell Death by a Designed hIAPP Amyloid- Core-Containing Hexapeptide

Marianna Tatarek‐Nossol, Limei Yan, Anke Schmauder, +3

Chemistry & Biology

Hiapp Amyloid-fibril FormationAlzheimer's DiseaseBiochemistryMedicineNatural Sciences +6

A Hot‐Segment‐Based Approach for the Design of Cross‐Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self‐Assembly

Erika Andreetto, Eleni Malideli, Limei Yan, +11

Angewandte Chemie International Edition

Protein AssemblyPeptide EngineeringMolecular Self-assemblyMolecular BiologyCross-seeded Iapp Self-assembly +18

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

Daniel Sellin, Limei Yan, Aphrodite Kapurniotu, +1

Biophysical Chemistry

Iapp FibrillationProteinlipid InteractionAnionic Lipid MembranesBiochemistryMedicine +5

Role of microRNA-21 in regulating 3T3-L1 adipocyte differentiation and adiponectin expression

Min Kang, Limei Yan, Wenyu Zhang, +3

Molecular Biology Reports

Transcriptional RegulationSystems BiologyMolecular PhysiologyMetabolic RegulationMicrorna Detection +8

Lewis (y) Antigen Overexpression Increases the Expression of MMP-2 and MMP-9 and Invasion of Human Ovarian Cancer Cells

Limei Yan, Bei Lin, Lili Gao, +6

International Journal of Molecular Sciences

ImmunologyImmunoeditingImmunotherapeuticsCancer BiologyTumor Biology +15

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

Maria Bakou, Kathleen Hille, Michael Kracklauer, +7

Journal of Biological Chemistry

Amyloid Self-assemblyProtein AssemblyBiochemistryProtein FoldingNatural Sciences +8