IAPP Mimic Blocks Aβ Cytotoxic Self‐Assembly: Cross‐Suppression of Amyloid Toxicity of Aβ and IAPP Suggests a Molecular Link between Alzheimer's Disease and Type II Diabetes

Abstract

Le fabuleux destin d'amyloid disease: A peptide-derived inhibitor for amyloid diseases binds the Alzheimer's disease β-amyloid peptide (Aβ40) and the type II diabetes islet amyloid polypeptide (IAPP) and blocks cytotoxic self-assembly of both peptides. Evidence is also presented for a high-affinity interaction between Aβ40 and IAPP that results in cross-suppression of cytotoxic self-association of both peptides.