Physicochemical Properties and Transport of Steroids Across Caco-2 Cells

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Goodman and Gilman's the Pharmacological Basis of Therapeutics

William H. Stigelman, D Pharm · Military Medicine · 1986 · 6.8K citations

Medicine, Pharmacology, Pharmacotherapy +6

In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth

Shiyin Yee · Pharmaceutical Research · 1997 · 1K citations

Pharmacy, Cell Biology, Physiology +13

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

Shinji Yamashita, Tomoyuki Furubayashi, Makoto Kataoka et al. · European Journal of Pharmaceutical Sciences · 2000 · 565 citations

Pharmacy, Pharmaceutics, Pharmacology +14