The Journal of Experimental Medicine · 2006 · 522 citations · 39 references
Life SciencesImmunologyMolecular BiologyCellular ImmunologyGene ExpressionImmunoregulationImmune RegulationMicrorna BiologyRegulatory T CellsT Cell BiologyT Cell DevelopmentThymic DevelopmentCd4 Positive T CellsDicer-mediated ProcessingFoxp3 BiologyMicrorna In Immune RegulationMicrorna-mediated Immune RegulationT Helper Cell DevelopmentThymic Regulatory T Cell DevelopmentThymic Regulatory T Cells
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell-like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor beta. These results suggest that T reg cell development involves Dicer-generated RNAs.
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In silico prediction of protein-protein interactions in human macrophages
Oussema Souiai, Fatma Z. Guerfali, Slimane Ben Miled et al. · BMC Research Notes · 2014 · 11K citations · Full text