Concepedia

Dicer-mediated Processing

Dicer-Mediated Processing is a molecular mechanism in small non-coding RNA biogenesis wherein the RNase III endonuclease Dicer selectively cleaves double-stranded RNA precursors into mature short interfering RNAs (siRNAs) or microRNAs (miRNAs), thereby defining the length and functionality of the resulting small regulatory RNAs.

484

Publications

76.3K

Citations

2.6K

Authors

774

Institutions

Publications per year

2017–2026

97

Parents

Publications

484

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the <i>let-7</i> Small Temporal RNA

György Hutvágner, Juanita McLachlan, Amy E. Pasquinelli et al. · Science · 2001 · 2.6K citations

, , +15

Functional siRNAs and miRNAs Exhibit Strand Bias

Anastasia Khvorova, Angela Reynolds, Sumedha D. Jayasena · Cell · 2003 · 2.6K citations · Full text

, , +14

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy et al. · Nature · 2005 · 2.1K citations · Full text

, , +14

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

György Hutvágner, Phillip D. Zamore · Science · 2002 · 2.1K citations

, , +17

Dicer is essential for mouse development

Emily Bernstein, Sang Yong Kim, Michelle A. Carmell et al. · Nature Genetics · 2003 · 1.9K citations

, , +7

1–5 of 484

Authors

2.6K

  1. EC
    Eric C. Lai

    Kettering University, United States

    11 publications · 1.1K citations

    11

    h-index

  2. JA
    Jennifer A. Doudna

    University of California, Berkeley, United States

    11 publications · 3.6K citations

    11

    h-index

  3. BB
    Brenda Bass

    University of Utah, United States

    11 publications · 1.7K citations

    11

    h-index

  4. GJ
    Gregory J. Hannon

    Cold Spring Harbor Laboratory, United States

    8 publications · 6.5K citations

    8

    h-index

  5. PP
    Patrick Provost

    Université Laval, Canada

    8 publications · 1.2K citations

    8

    h-index

1–5 of 2.6K

Institutions

774

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    33 h-index

    96 publications

    40.7K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    88 publications

    8.5K citations

  3. Harvard University

    Cambridge, United States

    13 h-index

    27 publications

    9.3K citations

  4. University of California, Berkeley

    Berkeley, United States

    12 h-index

    42 publications

    15.7K citations

  5. The University of Tokyo

    Tokyo, Japan

    12 h-index

    44 publications

    5.5K citations

  6. Kettering University

    Flint, United States

    11 h-index

    37 publications

    7.4K citations

  7. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    69 publications

    8.8K citations

  8. University of Utah

    Salt Lake City, United States

    11 h-index

    37 publications

    3.1K citations

1–8 of 774

Venues

  1. Nucleic Acids Research

    43 publications · 3.8K citations

    32

    h-index

  2. RNA

    32 publications · 5.3K citations

    26

    h-index

  3. PLoS ONE

    30 publications · 1.7K citations

    22

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 22 publications · 4.7K citations

    20

    h-index

  5. Cell

    12 publications · 6.4K citations

    12

    h-index

1–5