Quantitative Determination of Phenols in Mainstream Smoke with Solid-Phase Microextraction-Gas Chromatography--Selected Ion Monitoring Mass Spectrometry

Abstract

A method that uses solid-phase microextraction—gas chromatography—selected ion mode mass spectroscopy has been developed for the quantitative determination of phenolic compounds in cigarette smoke condensate. The concentrations of phenol, o-, m-, and p-cresol, 2-methoxyphenol, 2,6-dimethylphenol, 2,4-dimethylphenol, 2,5-dimethylphenol, 4-ethylphenol, 3-ethylphenol, 2,4,6-trimethylphenol, 4-methoxyphenol, 3-methoxyphenol, vanillin, 1-napthol, and 2-napthol present in Kentucky Reference 2R1F and five commercial cigarette brands are determined. Minimal sample preparation is required, and no organic solvents or derivatization reagents are necessary.