Diazonamide A and a Synthetic Structural Analog: Disruptive Effects on Mitosis and Cellular Microtubules and Analysis of Their Interactions with Tubulin

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

Medicine, Oncology, Pharmacology +10

The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

George R. Pettit, Yoshiaki Kamano, Cherry L. Herald et al. · Journal of the American Chemical Society · 1987 · 577 citations

Pharmacy, Toxicology, Analytical Toxicology +10

Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis

Niels Lindquist, William Fenical, Gregory D. Van Duyne et al. · Journal of the American Chemical Society · 1991 · 338 citations

Pharmacy, Marine Biology, Biochemical Toxicology +7

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

R Bai, George R. Pettit, Ernest Hamel · Journal of Biological Chemistry · 1990 · 286 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties.

Florenz Sasse, HEINRICH SIEINMETZ, J. R. HEIL et al. · The Journal of Antibiotics · 2000 · 254 citations · Full text

Life Sciences, Biochemistry, Microbiology +15