Concepedia

Structure Determination of Vitamin A Acetate Isomers through Coupled HPLC and <sup>1</sup>H NMR Spectroscopy

Klaus Albert, Götz Schlotterbeck, Ulrich Braumann, Heidrun Händel, Manfred Spraul, Gerhard Krack

Angewandte Chemie International Edition in English · 1995 · 32 citations · 13 references

DOI

Concepts

Abstract

Even though their HPLC peaks overlap, vitamin A acetate isomers 1 (11-cis) and 2 (11,13-di-cis) can be distinguished and their 1H NMR spectra measured. Coupled HPLC and 1H NMR spectroscopy is the method of choice.

References

13

Development of Engineered Stationary Phases for the Separation of Carotenoid Isomers

Lane C. Sander, Katherine E. Sharpless, Neal E. Craft et al. · Analytical Chemistry · 1994 · 363 citations

, , +17

High-performance liquid chromatography coupled to high-field proton nuclear magnetic resonance spectroscopy: application to the urinary metabolites of ibuprofen

Manfred Spraul, Martin Hofmann, Péter Dvortsák et al. · Analytical Chemistry · 1993 · 127 citations

, , +17

High-performance liquid chromatography—nuclear magnetic resonance on-line coupling

Klaus Albert, Ernst Bayer · TrAC Trends in Analytical Chemistry · 1988 · 53 citations

, , +9

Use of liquid chromatography-nuclear magnetic resonance spectroscopy for the identification of impurities in drug substances

John K. Roberts, Richard J. Smith · Journal of Chromatography A · 1994 · 51 citations

, , +14

High-performance liquid chromatographic determination of carotene and vitamin A and its geometric isomers in foods

Bruno Stancher, F Zonta · Journal of Chromatography A · 1982 · 50 citations

, , +14