High Frequency of Germline <i>SUFU</i> Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of Age

Abstract

These data indicate that germline SUFU mutations were responsible for a high proportion of desmoplastic medulloblastoma in children younger than 3 years of age. Genetic testing should be offered to all children diagnosed with sonic hedgehog-driven medulloblastoma at a young age.