Molecular subgroups of medulloblastoma: the current consensus

Michael D. Taylor, Paul A. Northcott, Andrey Korshunov, +13

Acta Neuropathologica

BiologyNeuro-oncologyMain SubgroupsProtistTumor Heterogeneity +10

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

Leonora Balaj, Ryan Lessard, Lixin Dai, +4

Nature Communications

Tumor HeterogeneityRetrotransposon ElementsMedicineCell BiologyTumor Microenvironment +1

The whole-genome landscape of medulloblastoma subtypes

Paul A. Northcott, Ivo Buchhalter, A. Sorana Morrissy, +84

Nature

Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas

Sebastian Bender, Yujie Tang, Anders M. Lindroth, +38

Cancer Cell

Neuro-oncologyRadiation OncologyPediatric Brain TumorsCancer Cell BiologyCancer Genomics +7

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

Yoon-Jae Cho, Aviad Tsherniak, Pablo Tamayo, +17

Journal of Clinical Oncology

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

Boris G. Wilson, Xi Wang, Xiaohua Shen, +7

Cancer Cell

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsEpigenomics +7

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

Hendrik Witt, Stephen C. Mack, Marina Ryzhova, +31

Cancer Cell

Posterior Fossa EpendymomaSurgical PathologyPathologyMolecularly Distinct SubgroupsMedicine

Subgroup-Specific Prognostic Implications of <i>TP53</i> Mutation in Medulloblastoma

Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, +57

Journal of Clinical Oncology

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

Sharareh Gholamin, Siddhartha S. Mitra, Abdullah H. Feroze, +31

Science Translational Medicine

Clonal selection drives genetic divergence of metastatic medulloblastoma

Xiaochong Wu, Paul A. Northcott, Adrian M. Dubuc, +29

Nature

Somatic VariantTumor HeterogeneityMedicineGeneticsPathology +3