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Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Andrew Potter, Victoria Oldfield, Claire L. Nunns, Christophe Fromont, Stuart Ray, Christopher J. Northfield, Chris Bryant, Simon Scrace, David A. Robinson, Natalia Matossova,

Bioorganic & Medicinal Chemistry Letters · 2010 · 97 citations · 29 references

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29

A Specific Mechanism of Nonspecific Inhibition

Susan L. McGovern, Brian T. Helfand, Brian Y. Feng et al. · Journal of Medicinal Chemistry · 2003 · 605 citations · Full text

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

Nick R. Brown, M.E.M. Noble, Jane Endicott et al. · Nature Cell Biology · 1999 · 552 citations

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Pin1-Dependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Proteins

Xiao Zhen Zhou, Oliver Kops, Andreas Werner et al. · Molecular Cell · 2000 · 532 citations · Full text

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Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1

Gerburg M. Wulf · The EMBO Journal · 2001 · 530 citations · Full text

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Prevalent Overexpression of Prolyl Isomerase Pin1 in Human Cancers

Lere Bao, Amy Kimzey, Guido Sauter et al. · American Journal Of Pathology · 2004 · 375 citations · Full text

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