TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

Dafni‐Eleftheria Pefani, Daniela Paňková, Aswin Abraham, +4

Molecular Cell

Signal TransductionDevelopmental BiologySignaling PathwayReceptor Tyrosine KinaseMedicine +3

ATM Regulates a RASSF1A-Dependent DNA Damage Response

Garth Hamilton, Karen S. Yee, Simon Scrace, +1

Current Biology

ChromatinGeneticsGenome InstabilityMedicine

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Andrew Potter, Victoria Oldfield, Claire L. Nunns, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryNatural SciencesMedicine +7

JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations

Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, +95

EngineeringGeneticsDigital PathologyPathologyTumor Biology +22

Structure-guided design of α-amino acid-derived Pin1 inhibitors

Andrew Potter, Stuart Ray, Louisa Gueritz, +12

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMolecular PharmacologyMedicinal ChemistryMedicineRational Drug Design +4

Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated Invasion

Nikola Vlahov, Simon Scrace, Manuel Sarmiento Soto, +10

Current Biology

Identification of novel,<i>in vivo</i>active Chk1 inhibitors utilizing structure guided drug design

Andrew J. Massey, S.P. Stokes, Helen Browne, +10

Oncotarget

Use of the xCELLigence System for Real-Time Analysis of Changes in Cellular Motility and Adhesion in Physiological Conditions

Simon Scrace, Eric O’Neill, Ester M. Hammond, +1

Methods in molecular biology

Disruption of tumour-host communication by downregulation of LFA-1 reduces COX-2 and e-NOS expression and inhibits brain metastasis growth

Manuel Sarmiento Soto, Emma R. O’Brien, Kleopatra Andreou, +5

Oncotarget

RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis

Maria Laura Tognoli, Nikola Vlahov, Sander Christiaan Steenbeek, +12

The EMBO Journal