Christophe Fromont

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

M.S. Halliday, Helois Radford, Yusuke Sekine et al. · Cell Death and Disease · 2015 · 369 citations · Full text

Structure-Activity Relationships in Purine-Based Inhibitor Binding to HSP90 Isoforms

Lisa Wright, Xavier Barril, Brian Dymock et al. · Chemistry & Biology · 2004 · 265 citations · Full text

Hsp90 Isoforms, Signal Transduction, Biochemistry +5

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

Alisa Zyryanova, Félix Weis, Alexandre Faille et al. · Science · 2018 · 221 citations · Full text

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-<i>d</i>]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

Paul A. Brough, Xavier Barril, Jenifer Borgognoni et al. · Journal of Medicinal Chemistry · 2009 · 173 citations · Full text

Design and Characterization of Libraries of Molecular Fragments for Use in NMR Screening against Protein Targets

Nicolas Baurin, Fareed Aboul‐ela, Xavier Barril et al. · Journal of Chemical Information and Computer Sciences · 2004 · 130 citations

Drug Target, Structural Bioinformatics, Biomolecular Structure Prediction +19