Concepedia

Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells

Yasuhiro Nemoto, Takanori Kanai∥, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe

Gut · 2012 · 67 citations · 17 references

DOIFull text

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Abstract

We demonstrate for the first time that BM MSC are a major source of IL-7 and play a pathological role in IBD by forming the niche for colitogenic CD4 memory T cells in BM.

References

17

A human memory T cell subset with stem cell–like properties

Luca Gattinoni, Enrico Lugli, Yun Ji et al. · Nature Medicine · 2011 · 1.9K citations · Full text

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Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type

Mikako Sasaki, Riichiro Abe, Yasuyuki Fujita et al. · The Journal of Immunology · 2008 · 1K citations · Full text

Stimulation of B-cell progenitors by cloned murine interleukin-7

A E Namen, Stephen D. Lupton, Kathryn Hjerrild et al. · Nature · 1988 · 813 citations

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Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

Manuel A. Rivas, Mélissa Beaudoin, Agnès Gardet et al. · Nature Genetics · 2011 · 776 citations · Full text

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Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study

Marjolijn Duijvestein, Anne Christine W. Vos, Helene Roelofs et al. · Gut · 2010 · 620 citations