Takanori Kanai∥

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Mami Matano, Shoichi Date, Mariko Shimokawa et al. · Nature Medicine · 2015 · 1.1K citations

Colorectal Cancer, Genome Engineering, Gene Editing +6

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date et al. · Cell stem cell · 2016 · 823 citations · Full text

Tumor Biology, Oncology, Tumor Heterogeneity +9

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa, Yuki Ohta, Shingo Nishikori et al. · Nature · 2017 · 728 citations

Tumor Biology, Biological Microenvironments, Cancer Genomics +6

Evidence-based clinical practice guidelines for inflammatory bowel disease

Katsuyoshi Matsuoka, Taku Kobayashi, Fumiaki Ueno et al. · Journal of Gastroenterology · 2018 · 684 citations · Full text

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa et al. · Cell stem cell · 2018 · 614 citations

Tumor Biology, Lineage Plasticity, Pancreatic Cancer +9