Takanori Kanai∥

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

Mami Matano, Shoichi Date, Mariko Shimokawa et al. · Nature Medicine · 2015 · 1.1K citations

Life Sciences, Biotechnology, Molecular Biology +16

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Masayuki Fujii, Mariko Shimokawa, Shoichi Date et al. · Cell stem cell · 2016 · 853 citations · Full text

Medicine, Cancer Biology, Oncology +12

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa, Yuki Ohta, Shingo Nishikori et al. · Nature · 2017 · 749 citations

Medicine, Cell Biology, Oncology +10

Evidence-based clinical practice guidelines for inflammatory bowel disease

Katsuyoshi Matsuoka, Taku Kobayashi, Fumiaki Ueno et al. · Journal of Gastroenterology · 2018 · 693 citations · Full text

Medicine, Clinical Sciences, Internal Medicine +15

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Takashi Seino, Shintaro Kawasaki, Mariko Shimokawa et al. · Cell stem cell · 2018 · 638 citations

Medicine, Cell Biology, Oncology +14