Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex - Concepedia

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Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

DOI Full Paper Access

152

Citations

32

References

2008

Year

Ioannis P. Trougakos, Magda Lourda, Marianna H. Antonelou, Dimitris Kletsas, Vassilis G. Gorgoulis, Issidora S. Papassideri, Yonglong Zou, Lukas H. Margaritis, David A. Boothman, Efstathios S. Gonos

Clinical Cancer Research

Abstract

We suggest that elevated sCLU levels may enhance tumorigenesis by interfering with Bax proapoptotic activities and contribute to one of the major characteristics of cancer cells, that is, resistance to apoptosis.

References

	Year	Citations

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