Concepedia

Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale

Sachiko Tsukamoto, Keiichirou Koimaru, Tomihisa Ohta

Marine Drugs · 2005 · 38 citations · 19 references

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Abstract

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-45 μg/mL.

References

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