Concepedia

AKT Participates in Endothelial Dysfunction in Hypertension

Guido Iaccarino, Michele Ciccarelli, Daniela Sorriento, Ersilia Cipolletta, Vincenzo Cerullo, Gianni Luigi Iovino, Alessandro Paudice, Andrea Elia, Gaetano Santulli, Alfonso Campanile,

Circulation · 2004 · 98 citations · 33 references

DOI

Abstract

We conclude that AKT participates in the settings of endothelial dysfunction in SHR rats by impaired membrane localization. Our data suggest that AKT is involved in endothelium dysfunction in hypertension.

References

33

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations

Endothelial Cells, Cellular Physiology, Oxidative Stress +17

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

David Fulton, Jean‐Philippe Gratton, Timothy J. McCabe et al. · Nature · 1999 · 2.6K citations

Inflammation, Signal Transduction, Molecular Physiology +11

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.5K citations · Full text

Tumor Biology, Signal Transduction, Signaling Pathway +12

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

Boudewijn Burgering, Paul J. Coffer · Nature · 1995 · 2.1K citations

Signal Transduction, Molecular Physiology, Signaling Pathway +8

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

Paul L. Huang, Zhihong Huang, Hiroshi Mashimo et al. · Nature · 1995 · 2.1K citations

Hypertension, Molecular Physiology, Cardiovascular Disease +9