Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis

Abstract

These results demonstrate that the intra-articular injection of rapamycin could reduce mTOR expression, leading to a delay in articular cartilage degradation in our OA murine model. Our observations suggest that local intra-articular injection of rapamycin could represent a potential therapeutic approach to prevent OA.