Concepedia

Publication | Open Access

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

DOIFull Paper Access

352

Citations

40

References

2010

Year

John R. Ussher, Timothy R. Koves, Virgilio J. J. Cadete, Liyan Zhang, Jagdip S. Jaswal, Suzanne J. Swyrd, David G. Lopaschuk, Spencer D. Proctor, Wendy Keung, Deborah M. Muoio,
Diabetes

Abstract

Our results demonstrate that the intramyocellular accumulation of ceramide correlates strongly with the development of insulin resistance, and suggests that inhibition of SPT1 is a potentially promising target for the treatment of insulin resistance.

References

YearCitations

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