Chemistry & Biodiversity · 2009 · 14 citations · 7 references
Life SciencesMedicinal ChemistryPharmacologyMolecular VirologySynthetic Medicinal ChemistryVirologyAntiretroviral TherapyAntiviral AgentsAntiviral PharmacologyEnzyme InhibitionAntiviral Structure-activity RelationshipsNon-nucleoside AntiviralsNon-nucleoside InhibitorsNon-nucleoside Reverse Transcriptase InhibitorsNonnucleoside InhibitorsNucleoside AnalogsPyrimidine AnaloguesViral Replication Inhibitors
A series of diaryltriazine derivatives modified at C(2) of the triazine ring with a fluorinated phenyl group has been synthesized and tested for the ability to inhibit HIV-1 replication. Most of these F-containing compounds showed low-to-moderate anti-HIV activity in MT-4 cells.
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Kalyan Das, Arthur D. Clark, Paul Lewi et al. · Journal of Medicinal Chemistry · 2004 · 511 citations
Fluorine chemistry at the millennium
William R. Dolbier · Journal of Fluorine Chemistry · 2004 · 398 citations