N,N′-Dimethoxy-N,Nt-Dimethylethanediamide: A Useful α-Oxo-N-Methoxy-N-Methylamide and 1,2-Diketone Synthon

N-methoxy-n-methylamides as effective acylating agents

Steven Nahm, Steven M. Weinreb · Tetrahedron Letters · 1981 · 1.8K citations

Pharmacy, Medicinal Chemistry, Pharmacology +5

.alpha.-Diketone and .alpha.-keto ester derivatives of N-protected amino acids and peptides as novel inhibitors of cysteine and serine proteinases

Michael R. Angelastro, Shujaath Mehdi, Joseph P. Burkhart et al. · Journal of Medicinal Chemistry · 1990 · 146 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthetic studies in the lysocellin family of polyether antibiotics. The total synthesis of ferensimycin B

David A. Evans, Richard P. Polniaszek, Keith M. DeVries et al. · Journal of the American Chemical Society · 1991 · 99 citations

Pharmacy, Medicinal Chemistry, Drug Design +10

Reaction of singlet oxygen with enamino carbonyl systems. A general method for the synthesis of .alpha.-keto derivatives of lactones, esters, amides, lactams, and ketones

Harry H. Wasserman, Jeffrey L. Ives · The Journal of Organic Chemistry · 1985 · 95 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

.alpha.-Amino acids as chiral educts for asymmetric products. The synthesis of .alpha.'-amino-.alpha.,.beta.-ynones

Thomas L. Cupps, Raymond H. Boutin, Henry Rapoport · The Journal of Organic Chemistry · 1985 · 86 citations

Natural Sciences, Biochemistry, Chemistry +12