Acceleration of Multicomponent Reactions in Aqueous Medium: Multicomponent Synthesis of a 4H-pyran Library

Abstract

A combinatorial library of 2-amino-4H-pyran derivatives has been developed by a threecomponent reaction between aldehyde, malononitrile and -dicarbonyl compounds (ethyl acetoacetate or acetylacetone) in the presence of ammonium acetate in aqueous medium. This protocol couples the benefits of multi-component reaction (MCR) with those of water as solvent for organic transformations, thus facilitating efficient chemical production in an environmentally benign way.