Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

M.Dodson Michael, Rohit Kulkarni, Catherine Postic et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Medicine, Cell Biology, Endocrinology +17

Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

Rohit Kulkarni, Jens C. Brüning, Jonathon N. Winnay et al. · Cell · 1999 · 1.2K citations · Full text

Life Sciences, Endocrinology, Physiology +17

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

Jie Wang, Toshiyuki Takeuchi, Shigeyasu Tanaka et al. · Journal of Clinical Investigation · 1999 · 570 citations · Full text

Medicine, Endocrinology, Molecular Biology +17

Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

Johanna ten Hoeve, Marı́a de Jesús Ibarra-Sánchez, Yubin Fu et al. · Molecular and Cellular Biology · 2002 · 499 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2

Yoshiaki Kido, Deborah J. Burks, Dominic J. Withers et al. · Journal of Clinical Investigation · 2000 · 496 citations · Full text

Medicine, Endocrinology, Molecular Genetics +17