Mechanism of Carbamate Inactivation of FAAH: Implications for the Design of Covalent Inhibitors and In Vivo Functional Probes for Enzymes

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

William A. Devane, Aviva Breuer, Roger G. Pertwee et al. · Science · 1992 · 5.6K citations

Life Sciences, Neuroscience, Pharmacology +15

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

Benjamin F. Cravatt, Dan K. Giang, Stephen P. Mayfield et al. · Nature · 1996 · 2.1K citations

Life Sciences, Biochemistry, Neuroscience +14

DTASelect and Contrast:  Tools for Assembling and Comparing Protein Identifications from Shotgun Proteomics

David L. Tabb, W. Hayes McDonald, John R. Yates · Journal of Proteome Research · 2002 · 1.4K citations

Life Sciences, Biochemistry, Bioinformatics +17

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Benjamin F. Cravatt, Kristin Demarest, Matthew P. Patricelli et al. · Proceedings of the National Academy of Sciences · 2001 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +13

Modulation of anxiety through blockade of anandamide hydrolysis

Satish Kathuria, Silvana Gaetani, Darren Fegley et al. · Nature Medicine · 2002 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +12