Concepedia

Targeting Small Cell Lung Cancer Harboring <i>PIK3CA</i> Mutation with a Selective Oral PI3K Inhibitor PF-4989216

Marlena Walls, Sangita M. Baxi, Pramod P. Mehta, Kevin K.‐C. Liu, JinJiang Zhu, Heather Estrella, Chunze Li, Michael Zientek, Qing Zong, Tod Smeal,

Clinical Cancer Research · 2013 · 33 citations · 20 references

DOIFull text

Open access

Abstract

Our results suggest that PF-4989216 is a potential cancer drug candidate for patients with SCLC with PIK3CA mutation but not PTEN loss.

References

20

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Jordi Barretina, Giordano Caponigro, Nicolas Stransky et al. · Nature · 2012 · 8.3K citations

, , +12

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

, , +10

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

Sally Bamford, Elisabeth Dawson, Simon Forbes et al. · British Journal of Cancer · 2004 · 1.3K citations · Full text

Bim: a novel member of the Bcl-2 family that promotes apoptosis

Liam O’Connor · The EMBO Journal · 1998 · 1.2K citations · Full text

, , +6

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.1K citations · Full text

, , +14