British Journal of Cancer · 2004 · 1.3K citations · 14 references
Life SciencesGeneticsOncologyCancer GeneticsGenomicsMolecular OncologyCancer Genome SequencingCancer GenomicsDna SequencingGenome SequencingGenomic DatabasesMutation AnalysisCancer Genomics DatabasesCancer Mutation AnalysisScientific Literature MiningSomatic Mutation AnalysisSomatic MutationsSomatic Variant AnalysisSomatic Variant Classification
The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.
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The Pfam Protein Families Database
Alex Bateman · Nucleic Acids Research · 2002 · 14.2K citations · Full text
Mutations of the BRAF gene in human cancer
Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations
The Pfam protein families database
Alex Bateman · Nucleic Acids Research · 2003 · 3.2K citations · Full text
Human Gene Mutation Database (HGMD<sup>®</sup>): 2003 update
Peter D. Stenson, Edward V. Ball, Matthew Mort et al. · Human Mutation · 2003 · 1.9K citations