A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

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High-Resolution Crystal Structure of an Engineered Human β ₂ -Adrenergic G Protein–Coupled Receptor

Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science · 2007 · 3.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

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A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

Laura A. Banaszynski, Ling-chun Chen, Lystranne A. Maynard-Smith et al. · Cell · 2006 · 958 citations · Full text

Life Sciences, Biochemistry, Cell Biology +10

siRNA-mediated gene silencing in vitro and in vivo

Haibin Xia, Qinwen Mao, Henry L. Paulson et al. · Nature Biotechnology · 2002 · 880 citations

Life Sciences, Genetics, Molecular Biology +11