Concepedia

siRNA-mediated gene silencing in vitro and in vivo

Haibin Xia, Qinwen Mao, Henry L. Paulson, Beverly L. Davidson

Nature Biotechnology · 2002 · 880 citations · 32 references

DOI

Concepts

References

32

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

, , +7

Role for a bidentate ribonuclease in the initiation step of RNA interference

Emily Bernstein, Amy A. Caudy, Scott M. Hammond et al. · Nature · 2001 · 4.9K citations

, , +15

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science · 2002 · 4.3K citations · Full text

, , +16

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

Scott M. Hammond, Emily Bernstein, David Beach et al. · Nature · 2000 · 3K citations

, , +14

RNAi

Phillip D. Zamore, Thomas Tuschl, Phillip A. Sharp et al. · Cell · 2000 · 2.6K citations · Full text