Neuronal replacement from endogenous precursors in the adult brain after stroke

Andreas Arvidsson, Tove Collin, Deniz Kirik, +2

Nature Medicine

Endogenous PrecursorsBrain CirculationSocial SciencesCerebral Vascular RegulationNeuroregeneration +15

Characterization of Behavioral and Neurodegenerative Changes Following Partial Lesions of the Nigrostriatal Dopamine System Induced by Intrastriatal 6-Hydroxydopamine in the Rat

Deniz Kirik, Carl Rosenblad, Anders Björklund

Experimental Neurology

Neurobiological MechanismNeuropsychologyBehavioral NeuroscienceNeuroanatomyNeurophysiology +10

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease

Martin Lundblad, Malin Andersson, Christian Winkler, +3

European Journal of Neuroscience

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

Deniz Kirik, Carl Rosenblad, Corinna Bürger, +5

PubMed

Neurodegenerative DiseasesParkinson-like NeurodegenerationMedicineHigh LevelPathology +12

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats

Manolo Carta, Thomas Carlsson, Deniz Kirik, +1

Brain

NeurotransmitterL-dopa-induced DyskinesiaSpared Serotonin Innervation5-Ht TerminalsParkinsonian Rats +16

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

Deniz Kirik, Carl Rosenblad, Corinna Bürger, +5

Journal of Neuroscience

Synaptic TransmissionDopamine NeuronsSynaptic SignalingSocial SciencesNigrostriatal System +21

Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System

Deniz Kirik, Carl Rosenblad, Anders Björklund, +1

Journal of Neuroscience

Lesioned Nigrostriatal SystemSocial SciencesNeuroregenerationLesioned StriatumNeurology +15

l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

Christian Winkler, Deniz Kirik, Anders Björklund, +1

Neurobiology of Disease

Health SciencesNeurophysiologyNeuroanatomyParkinson DiseasePhysiology +10

Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease

Deniz Kirik, Lucy E. Annett, Corinna Bürger, +3

Proceedings of the National Academy of Sciences

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

Mari Iwamoto, Tomas Björklund, Cecilia Lundberg, +2

Chemistry & Biology

Molecular PhysiologyMolecular NeuroscienceBiochemistryNeurophysiologyProtein Stability +12