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Structure–activity relationships of oxysterol-derived pharmacological chaperones for Niemann–Pick type C1 protein

Kenji Ohgane, Fumika Karaki, Tomomi Noguchi‐Yachide, Kosuke Dodo, Yuichi Hashimoto

Bioorganic & Medicinal Chemistry Letters · 2014 · 21 citations · 27 references

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27

An oxysterol signalling pathway mediated by the nuclear receptor LXRα

Bethany A. Janowski, Patricia J. Willy, Thota Rama Devi et al. · Nature · 1996 · 1.7K citations

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Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

Eugene D. Carstea, Jill A. Morris, Katherine Coleman et al. · Science · 1997 · 1.5K citations

, , +17

Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

Bethany A. Janowski, Michael J. Grogan, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 1999 · 937 citations

, , +14

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

Stacie K. Loftus, Jill A. Morris, Eugene D. Carstea et al. · Science · 1997 · 807 citations

, , +17

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

Hyock Joo Kwon, Lina Abi-Mosleh, Michael Wang et al. · Cell · 2009 · 670 citations · Full text

, , +14