Synthesis and evaluation of novel dual BRD4/HDAC inhibitors

Seika Amemiya, Takao Yamaguchi, Yuichi Hashimoto, +1

Bioorganic & Medicinal Chemistry

Medicinal ChemistryMedicineDrug DevelopmentPharmacologyPharmaceutical Chemistry +1

Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6<i>H</i>-dibenz[<i>b</i>,<i>e</i>]azepin-6-one Skeleton

Atsushi Aoyama, Kaori Endo‐Umeda, Kenji Kishida, +7

Journal of Medicinal Chemistry

Drug TargetCellular PharmacologySystems PharmacologyMolecular PharmacologyMedicinal Chemistry +17

Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists

Kazunori Motoshima, Tomomi Noguchi‐Yachide, Kazuyuki Sugita, +2

Bioorganic & Medicinal Chemistry

Lxrα-selective AntagonistsPharmaceutical ScienceBiochemistryMedicinePharmacological Agent +6

Antiproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (−)-epigallocatechin gallate

Kosuke Dodo, Taro Minato, Tomomi Noguchi‐Yachide, +2

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBiochemistryMedicineNatural Sciences +5

β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity

Yuji Fujita, Mitsuhiro Yonehara, Masashi Tetsuhashi, +3

Bioorganic & Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicineNatural SciencesMechanism Of Action +8

Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors

Tomomi Noguchi‐Yachide, Atsushi Aoyama, Makoto Makishima, +2

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineLiver PhysiologyNatural Sciences +10

Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development

Kosuke Dodo, Atsushi Aoyama, Tomomi Noguchi‐Yachide, +3

Bioorganic & Medicinal Chemistry

Molecular PharmacologySignal TransductionStructural DevelopmentBiochemistryNatural Sciences +8

LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators

Yusuke Mita, Kosuke Dodo, Tomomi Noguchi‐Yachide, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesPeptide Library +6

Structure–activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators

Yusuke Mita, Kosuke Dodo, Tomomi Noguchi‐Yachide, +2

Bioorganic & Medicinal Chemistry

Structure–activity RelationshipMolecular PharmacologyBiochemistryMedicineBenzodiazepine Derivatives +8

Enhancement of Chemically-Induced HL-60 Cell Differentiation by 3,3'-Diindolylmethane Derivatives

Tomomi Noguchi‐Yachide, Masashi Tetsuhashi, Hiroshi Aoyama, +1

Chemical and Pharmaceutical Bulletin