Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Wenli Liu, Nataliya Östberg, Mustafa Yalçınkaya, +11

Journal of Clinical Investigation

Vascular DiseaseLipid PeroxidationImmunologyPathologyHyperlipidemia +20

Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion

Mustafa Yalçınkaya, Panagiotis Fotakis, Wenli Liu, +8

Cardiovascular Research

Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis

Kaori Endo‐Umeda, Eun Young Kim, David G. Thomas, +11

Arteriosclerosis Thrombosis and Vascular Biology

Design, Synthesis, and Biological Evaluation of Novel Transrepression-Selective Liver X Receptor (LXR) Ligands with 5,11-Dihydro-5-methyl-11-methylene-6<i>H</i>-dibenz[<i>b</i>,<i>e</i>]azepin-6-one Skeleton

Atsushi Aoyama, Kaori Endo‐Umeda, Kenji Kishida, +7

Journal of Medicinal Chemistry

Drug TargetCellular PharmacologySystems PharmacologyMolecular PharmacologyMedicinal Chemistry +17

Liver X receptors regulate hepatic F4/80 + CD11b+ Kupffer cells/macrophages and innate immune responses in mice

Kaori Endo‐Umeda, Hiroyuki Nakashima, Shihoko Komine‐Aizawa, +3

Scientific Reports

Vitamin D Receptor Activation Enhances Benzo[a]pyrene Metabolism via CYP1A1 Expression in Macrophages

Manabu Matsunawa, Daisuke Akagi, Shigeyuki Uno, +4

Drug Metabolism and Disposition

Increased SLAMF7high monocytes in myelofibrosis patients harboring JAK2V617F provide a therapeutic target of elotuzumab

Takaaki Maekawa, Shoichiro Kato, Toshikuni Kawamura, +26

Blood

Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators

S. Nomura, Kaori Endo‐Umeda, Atsushi Aoyama, +3

ACS Medicinal Chemistry Letters

Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

Masayuki Chuma, Kaori Endo‐Umeda, Shigeki Shimba, +2

Biological and Pharmaceutical Bulletin

Differential Expression and Function of Alternative Splicing Variants of Human Liver X Receptor α

Kaori Endo‐Umeda, Shigeyuki Uno, Ko Fujimori, +8

Molecular Pharmacology