Metformin reduces airway glucose permeability and hyperglycaemia-induced <i>Staphylococcus aureus</i> load independently of effects on blood glucose

Abstract

Hyperglycaemia promotes respiratory S aureus infection, and metformin modifies glucose flux across the airway epithelium to limit hyperglycaemia-induced bacterial growth. Metformin might, therefore, be of additional benefit in the prevention and treatment of respiratory infection.