Acetyl-Boswellic Acids Are Novel Catalytic Inhibitors of Human Topoisomerases I and IIα

Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

Emily Pisha, Heebyung Chai, Ik‐Soo Lee et al. · Nature Medicine · 1995 · 886 citations

Life Sciences, Medicinal Chemistry, Pharmacology +14

Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods

Daniel J. O’Shannessy, Michael Brigham‐Burke, K. Karl Soneson et al. · Analytical Biochemistry · 1993 · 551 citations

Natural Sciences, Biophysics, Chemistry +14

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

Hasan Safayhi, T. Mack, J. Sabieraj et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 396 citations

Life Sciences, Biochemistry, Pharmacology +15

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

Joaquím Roca, Ryoji Ishida, James M. Berger et al. · Proceedings of the National Academy of Sciences · 1994 · 354 citations · Full text

Medicine, Molecular Biology, Pharmacology +12

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations · Full text

Life Sciences, Cell Biology, Oncology +17