The Journal of Immunology · 2009 · 271 citations · 42 references
Life SciencesCell BiologyImmunologyAutoimmunityImmunoregulationInflammationCytokine BiologyCytokine RegulationDendritic Cell BiologyImmune RegulationRegulatory T CellsT Cell BiologyCytokine-mediated SuppressionDifferentiationDifferentiation Signaling PathwaysInflammatory T Cell ResponsesInterleukin-10 Production By Regulatory T CellsInterleukin-17 PathwayTh17 Cell DifferentiationTr1 Cells
Although the physiologic pathways that control regulatory T cells (Foxp3-expressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined, the factors that control these differentiation pathways in humans are not well understood. In this study, we show that IL-27 promotes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules associated with Th17 function. Furthermore, IL-27 inhibits IL-17-polarizing cytokines on dendritic cells, which in turn decrease IL-17 secretion from T cells. Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control autoimmunity and tissue inflammation.
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A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Hervé Groux, Anne O’Garra, Mike Bigler et al. · Nature · 1997 · 3.6K citations
Life Sciences, Immunology, Pathology +12
Transforming growth factor-β induces development of the TH17 lineage
Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature · 2006 · 3K citations