Concepedia
Annals of Oncology · 2007 · 22 citations · 8 references
Open access
OncologyMulticentre PhasePharmacologyPharmacokinetic StudyAdvanced Solid TumoursPharmacotherapyAnti-cancer AgentMetronomic ChemotherapyCancer TreatmentMedicineCancer Research
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Homocamptothecins: Synthesis and Antitumor Activity of Novel E-Ring-Modified Camptothecin Analogues
Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas et al. · Journal of Medicinal Chemistry · 1998 · 150 citations
Antitumor Activity, Chemoprevention Strategy, Tumor Growth Delay +17
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Laurence Lesueur‐Ginot, Danièle Demarquay, Róbert Kiss et al. · PubMed · 1999 · 109 citations
Chemoprevention Strategy, Cpt Analogues, Cell Death +16
Phase I and pharmacokinetic study of irinotecan (CPT-11) administered daily for three consecutive days every three weeks in patients with advanced solid tumors
G. Catimel, G G Chabot, Jean‐Paul Guastalla et al. · Annals of Oncology · 1995 · 107 citations · Full text
Oncology, Medicine, Pharmacokinetic Study +7
Topoisomerase I inhibitors: topotecan and irinotecan.
Suzanne F. Jones, Howard A. Burris · PubMed · 1996 · 69 citations
Molecular Pharmacology, Medicinal Chemistry, Medicine +6
Homocamptothecin, an E-Ring-Modified Camptothecin Analogue, Generates New Topoisomerase I-Mediated DNA Breaks
Christian Bailly, Amélie Lansiaux, Laurent Dassonneville et al. · Biochemistry · 1999 · 66 citations