Paola Principe

The induction of apoptosis is a common feature of the cytotoxic action of ether‐linked glycerophospholipids in human leukemic cells

Luisa Diombde, Bianca Piovani, Fabio Re et al. · International Journal of Cancer · 1994 · 41 citations

Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors.

Hans Gelderblom, Ramón Salazar, Jaap Verweij et al. · PubMed · 2003 · 39 citations

Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumours

Iñaki F. Trocóniz, Marı́a J. Garrido, Cristina Segura et al. · Cancer Chemotherapy and Pharmacology · 2005 · 36 citations

Dose-finding Study, Medicine, Pharmacology +7

Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors

Iñaki F. Trocóniz, J. M. Cendros, Elena Soto et al. · Cancer Chemotherapy and Pharmacology · 2012 · 25 citations

Oncology, Pharmacokinetic Modeling, Medicine +9

A multicentre phase I and pharmacokinetic study of BN80915 (diflomotecan) administered daily as a 20-min intravenous infusion for 5 days every 3 weeks to patients with advanced solid tumours

L. C. Scott, Otto Soepenberg, Jaap Verweij et al. · Annals of Oncology · 2007 · 22 citations · Full text

Oncology, Multicentre Phase, Pharmacology +8