Asparagine Deamidation Dependence on Buffer Type, pH, and Temperature

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Thermodynamic Quantities for the Ionization Reactions of Buffers

Robert N. Goldberg, Nand Kishore, Rebecca M. Lennen · Journal of Physical and Chemical Reference Data · 2002 · 693 citations

Natural Sciences, Biochemistry, Chemistry +13

Identification of multiple sources of charge heterogeneity in a recombinant antibody

Reed J. Harris, Bruce Kabakoff, Frank Macchi et al. · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 503 citations

Pharmacy, Biochemistry, Molecular Biology +16

Identification and Characterization of Deamidation Sites in the Conserved Regions of Human Immunoglobulin Gamma Antibodies

Dirk Chelius, Douglas S. Rehder, Pavel V. Bondarenko · Analytical Chemistry · 2005 · 263 citations

Life Sciences, Biochemistry, Molecular Biology +17

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

Josef Vlasak, Marie Claire Bussat, Shi‐Yi Wang et al. · Analytical Biochemistry · 2009 · 246 citations

Pharmacy, Chemical Biology, Molecular Biology +13