Association of <i>DHODH</i> Haplotype Variants and Response to Leflunomide Treatment in Rheumatoid Arthritis

Abstract

Carriage of a six-marker DHODH haplotype was associated with a reduced treatment response (p = 0.008). This suggests that a functional variant in strong linkage disequilibrium with this haplotype may predispose to reduced leflunomide efficacy.